gram negative bacteria

Mechanism of ActionAminoglycosides action include a large variety of antibiotic mechanisms, some as protein synthesis inhibitors. However, their exact mechanism of action is not exactly understood or fully known. Such mechanisms may include:Interfering with the proofreading process, in turn, increasing the rate of error in premature termination synthesis.Disrupting a bacterial cell membrane activity.Peptidyl tRNA traveling from the A site to P site through the inhibition of ribosomal translocation.Spectrum of ActivityThese antibiotics are most often used to treat infections involving aerobic, gram negative bacteria, such as Acinetobacter, Pseudomonas, and Enterobacter.

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